Aim: To explore the lived experiences of nurses and patients co-producing evidence-based care for long-term conditions, and to understand how they make sense of this process within relational, emotional, and organisational contexts.

Design: A qualitative study using Interpretative Phenomenological Approach.

Methods: Semi-structured interviews were conducted with 20 participants, comprising 11 registered nurses and 9 adult patients living with at least one Long Term Conditions. Participants were recruited from primary and secondary care settings across the Midlands, England. Data were collected between February and August 2023 and analysed using IPA’s iterative and inductive framework.

Results: Five experiential themes were identified: (1) weaving together different knowledges, (2) the relational foundations of co-production, (3) organisational pressures and misalignments, (4) shifting identities and power dynamics, and (5) emotional and ethical complexity in co-producing care. Participants described co-production as a deeply relational and negotiated process, shaped by trust, vulnerability, and shared decision-making.

Conclusion: Co-producing evidence-based care in Long Term Conditions management involves more than implementing guidelines. It is a relational, emotional, and contextual practice that requires shared interpretation of evidence, deep listening, and responsiveness to individual lives. Findings suggest a need to reframe EBP as a co-creative process grounded in relational ethics and contextual awareness.

Impact and implications: Findings emphasise the centrality of relational competence and organisational flexibility in enabling co-produced care. Findings call for educational and policy reforms that value emotional labour, professional humility, and patient knowledge as essential to evidence-based nursing. Internationally, this work provides a grounded model for integrating person-centred approaches into chronic care delivery and policy

Contribution to the wider global clinical community: The study offers a relational model of evidence-based practice that moves beyond protocol-driven care to one shaped through dialogue, empathy, and contextual negotiation, offering practical insights for transforming professional roles and health systems globally.

Patient and Public Involvement: Patient representatives contributed to study design, development of interview guides, and interpretation of findings to ensure alignment with lived experiences.

Reporting Method: This study follows the SRQR guideline.